WCG 新的任務推出 (研究流感病毒計畫)Influenza Antiviral Drug Search project

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引用 | 編輯 niceword
2009-05-06 14:08
樓主
推文 x2
今天收到WCG的新通知... 最近最紅的流感也被加入研究計畫中..

原文如下:

     
niceword.tw - your donated computer time can now help find drugs to combat a future outbreak of influenza!
World Community Grid has started a new research project that will use your donated computer time to find new drugs that can stop the spread of an influenza infection in an individual. The research will specifically address the influenza strains that have become drug resistant, as well as new strains that are appearing. Your computer will help identify the chemical compounds that are the best candidates. This will accelerate the efforts to develop treatments that would be useful in managing seasonal influenza outbreaks and future influenza epidemics.

If you are currently contributing and want to check to see if you are contributing to this project, click here. If you are no longer contributing but would like to contribute to this project, please click here.

For more information about the Influenza Antiviral Drug Search project or other projects running on World Community Grid, please click here.



Google翻譯如下:
niceword.tw -您捐贈的計算機時間現在可以幫助找到毒品,打擊未來爆發的流感!
全球社區網格已經開始了一項新的研究項目,該項目將使用自己的捐贈電腦的時間尋找新的藥物,可以停止傳播的流感感染的個人。這項研究將專門針對流感已成為耐藥性,以及新品種的出現。您的計算機將有助於確定化合物的最佳人選。這將加速努力,去開發治療,將是有用的管理季節性流感暴發和未來流感流行。

如果您正在作出貢獻,並希望檢查,看看您是否有助於這一項目,請點擊這裡。如果您不再貢獻,但希望有助於這一項目,請點擊這裡。

如需了解更多關於流感抗病毒藥物搜索項目或其他項目上運行的全球社區網格,請點擊這裡。


加入專案的方法和之前發布的文章一樣...
http://bbs.mychat.to/reads.php?tid=785783

建議~可以選全部加入..以後有新的專案就會自動加入...

一起加入造福人類吧~~

也希望這波流感大流行前..小小的電腦能夠提供一點心力協助研發~~~

一起加入吧~~

獻花 x0
引用 | 編輯 alexpon
2009-05-07 10:56
1樓
  
http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Main.do?utm_source=email&utm_medium=email&utm_campaign=flu1&language=en_US <--官網相關聯結
Influenza Antiviral Drug Search (抗流感藥物研究)

Project Status and Findings:
If you have comments or questions about this project, please visit the Influenza Antiviral Drug Search forum. For specific questions about the project, please go to the Influenza Antiviral Drug Search FAQs.

Mission
The mission of the Influenza Antiviral Drug Search project is to find new drugs that can stop the spread of an influenza infection in the body. The research will specifically address the influenza strains that have become drug resistant as well as new strains that are appearing. Identifying the chemical compounds that are the best candidates will accelerate the efforts to develop treatments that would be useful in managing seasonal influenza outbreaks, and future influenza epidemics and even pandemics.

Significance
Hundreds of thousands of people around the world die each year as a result of influenza infections. If a particularly virulent strain emerges that is readily transmitted among humans, a pandemic can potentially kill millions of people. The influenza virus mutates rapidly and therefore new varieties of influenza appear each year. Influenza vaccines are designed to anticipate the strains likely to be prevalent for the next flu season but can often miss newly evolved varieties. While drugs such as oseltamivir (commercial name Tamiflu) and zanamivir (commercial name Relenza) help keep influenza from spreading in the body, they do not work for all types of influenza and new drug resistant forms of influenza evolve and cannot be treated with these drugs. When drug resistant strains emerge, manufacturers designing vaccines may not be able to respond quickly enough to prevent a large outbreak of the disease. This project will search for promising new drug leads that stop the replication of the influenza viruses within the body, potentially helping patients who are not immune to a particular form of influenza. The discovery of both broad-spectrum and specific antiviral drugs is expected to significantly improve global health.

Approach
One promising approach to combat these viruses and prevent them from causing disease is to develop new drugs that inhibit neuraminidase (N1, N2, etc), NS1 protein, hemagglutinin, and possibly other targets that influenza needs to spread in the body. Using the known chemical structures of these target molecules, the project will perform virtual chemistry experiments and determine which of millions of known compounds attach to these target molecules in a manner that can disable or inhibit them, thus potentially keeping the influenza virus from spreading in the body. These experiments are performed using a program called AutoDock, from the Scripps Research Institute. This software is used for several other projects on World Community Grid. These include FightAIDS@Home, Discovering Dengue Drugs - Together, and Help Fight Childhood Cancer projects. Once drug candidates are identified using World Community Grid, then additional laboratory work, testing and ultimately drug trials will be required. This will likely not lead to any immediate treatments for influenza during the current H1N1 outbreak. However, influenza viruses cause recurrent seasonal disease outbreaks and have the potential for evolving into dangerous forms. Thus, proceeding on this project at this time will give us a better chance to be prepared for more serious outbreaks in the future.

又有新project 囉 加油
幫補充

獻花 x0